Drug Profiles Essays - Androgens, Sex Hormones, Anabolic Steroids

Drug Profiles Drug Profiles This is a list of steroids that can easily be found on the Internet Anadrol Anavar Androil Cheque Drops Clenbuterol Clomid Cyclofenil Cytadren Cytomel Deca-Durabolin Dianabol DNP Durabolon EPO Equipoise Esiclene Finaplix GHB Glucophage Halotestin HCG IGF-1 Implus Insulin Laurabolin Masteron Nolvadex Parabolan Phenformin Primobolan Depot Primoteston Depot 250 Proviron Ralgrow Revalor Sostanon 250 Sten Synovex Synthol Testosterone Cypionate Testosterone Enathate Testosterone Propinate Androstenedione What is Androstenedione? Androstenedione is a natural chemical found in the body that produces testosterone. This chemical can also be found naturally in some meat and even some plants. Androstenedione, also called Andro, can boost testosterone levels when taken orally sometimes making the person stronger. Andro was first seen in capsule form in the US in the 1990's. Its popularity has grown ever since Mark McGwire, the new Major League Baseball home run record holder, admitted to taking the supplement. The companies that are selling Andro are making huge profits off the supplement that claims to increase lean muscle mass 300%. Although most people who take the drug do not complain of any side effects at all, this drug has been reported to carry dangerous side effects. Most Major League sports have banned the supplement saying it gives athletes a unfair advantage. The NBA, the MLB, and the NHL in the US have not ruled this supplement as unfair. There are many questions that remain about this supplement such as the long-term side effects, and how much muscle is gained by taking the drug. This supplement can be bought over the counter and is not controlled by the FDA, making Andro easy to access. Some drug chains have taken this drug off the shelf due to fear of long-term side effects. Andro can be found in some local drug chains and also on the World Wide Web. One person from our poll explains, Andro's advantages make up for the side effects. What about the health risk? Most of the health risks for Androstenedione are not known, and the long-term effects are not known at all. ? It might convert to the female hormone, estrogen in males and females. ? Too much Andro can shut down the production of testosterone in the body. ? In adolescents, it is known to stunt growth. How does Andro work? Andro is first consumed orally. It is then taken to the liver where it picks up two carbons. The two carbons added to Andro are testosterone. Andro is also already made in your body. The natural production of Andro is different. What about Baseball and Andro? For more than a year St. Louis Cardinals, power hitter Mark McGwire has taken the legal, supplement Androstenedione. Many people believe that the drug gave him an unfair advantage last year when he shattered Roger Maris's single season home run record. Mark McGwire insists that the drug is legal and therefore should be a focal point in the media. He said, Everything I've done is natural. Everybody that I know in the game of baseball uses the same stuff I use. However, many other players have said that they would never a drug as strong as in Andro in fear of secondary problems. Many of these same players do not denounce McGwire for taking the drug. Mo Vaughn said, Anything illegal is definitely wrong. But if you get something over the counter and legal, guys in the power hitter position are going to use them. McGwire's use of the drug has brought it to the forefront and now many people are taking the supplement hoping for McGwire's success. Many of these people are teens participating in high school sports. Andro has different side effects in adolescents. A lot is still not known about Andro such as the long-term side effects. The FDA has no regulations against this supplement. This means that the FDA has found that the supplement is safe and will not stop any one from selling Andro unless they can prove that it is dangerous. This drug varies in side effects from person to person. One proven fact is that too much of any drug taken at one time it can cause dangerous side effects. In addition, it is still not known if the drug might

The Evolution of Insects From Prehistory Onward

The Evolution of Insects From Prehistory Onward Goliath beetles and sphinx moths would be described as large by just about anyone living today, but some prehistoric insects would dwarf these evolutionary descendants. During the Paleozoic era, the Earth teemed with giant insects, from dragonflies with wingspans measured in feet, to mayflies nearly 18 inches in breadth. While over a million insect species live today, truly giant insects no longer exist. Why did giant insects live in prehistoric times, but disappear from the Earth over time? When Were Insects the Biggest? The Paleozoic era occurred 542 to 250 million years ago. It is divided into six periods of time and the last two saw the development of the largest insects. These were known as the Carboniferous period (360 to 300 million years ago) and the Permian period (300 to 250 million years ago). Atmospheric oxygen is the single most limiting factor on insect size. During the Carboniferous and Permian periods, atmospheric oxygen concentrations were significantly higher than they are today. Prehistoric insects breathed air that was 31 to 35 percent oxygen, as compared to just 21 percent oxygen in the air youre breathing right now.   The largest insects lived during the Carboniferous period. It was the time of the dragonfly with over a two-foot wingspan and a millipede that could reach ten feet. As conditions changed in the Permian period, the bugs diminished in size. Yet, this period did have its share of giant cockroaches and other insects we would certainly classify as giants. How Did the Bugs Get So Big? The cells in your body get the oxygen they need to survive via your circulatory system. Oxygen is carried by the blood through your arteries and capillaries  to each and every cell in your body. In insects, on the other hand, respiration occurs by simple diffusion through the cell walls. Insects take in atmospheric oxygen through spiracles, openings in the cuticle through which gasses enter and exit the body. Oxygen molecules travel via the tracheal system. Each tracheal tube ends with a tracheole, where the oxygen dissolves into the tracheole fluid. The O2 then diffuses into the cells. When oxygen levels were higher as in the prehistoric era of giant insects this diffusion-limited respiratory system could supply sufficient oxygen to meet the metabolic needs of a larger insect. Oxygen could reach cells deep within the insects body, even when that insect measured several feet long. As atmospheric oxygen decreased over evolutionary time, these innermost cells could not be adequately supplied with oxygen. Smaller insects were better equipped to function in a hypoxic environment. And so, insects evolved into smaller versions of their prehistoric ancestors. The Biggest Insect That Ever Lived The current record holder for the largest insect that ever lived is an ancient griffenfly.  Meganeuropsis permiana  measured an impressive 71 cm from wing tip to wing tip, a full 28-inch wing span. This giant invertebrate predator inhabited what is now the central U.S. during the Permian period. Fossils of the species were discovered in Elmo, Kansas and Midco, Oklahoma. In some references, it is called  Meganeuropsis americana. Meganeuropsis permiana  is one of the prehistoric insects referred to as giant dragonflies. David Grimaldi, in his hefty volume  Evolution of the Insects, notes this is a misnomer. Modern day odonates are only distantly related to the giants known as prodonata. Other Giant, Ancient Arthropods An ancient sea scorpion,  Jaekelopterus rhenaniae, grew to 8 feet in length. Imagine a scorpion bigger than man! In 2007, Markus Poschmann unearthed a fossilized claw from this massive specimen in a German quarry. The claw measured 46 centimeters, and from this measurement, scientists were able to extrapolate the size of the prehistoric eurypterid (sea scorpion).  Jaekelopterus rhenaniae  lived between 460 and 255 million years ago. A millipede-like creature known as an  Arthropleura  reached equally impressive sizes.  Arthropleura  measured as long as 6 feet, and 18 inches wide. While paleontologists have yet to find a complete fossil of  Arthropluera, trace fossils found in Nova Scotia, Scotland, and the United States suggest the ancient millipede would rival an adult human being in size. Which Living Insects Are the Biggest? With well over one million insect species on Earth, the title of Biggest Living Insect would be an extraordinary achievement for any bug. Before we can confer such an award to a single insect, however, we need to determine how we measure bigness. What makes a bug big? Is it sheer bulk that defines a creature as large? Or something we measure with a ruler or tape measure, determined by centimeters? In truth, which insect wins the title depends on how you measure an insect, and who you ask. Measure an insect from the front of the head to the tip of the abdomen, and you can determine its body length. That might be one way to choose the biggest living insect. If thats your criteria, your newest world champion was crowned in 2008, when entomologists discovered a new stick insect species in Borneo. Chans megastick,  Phobaeticus chain, measures a full 14 inches from head to abdomen, and a full 22 inches if you stretch the tape measure to include its extended legs. Stick insects dominate the competition in the longest insect category. Prior to the discovery of Chans megastick, another walkingstick,  Pharnacia serratipes, held the title. For many insects, its wings spread far wider than the size of its body. Would wing span be a good measure of an insects size? If so, youre looking for a champion among the  Lepidoptera. Of all the living insects, butterflies and moths have the largest wing spans. The Queen Alexandras birdwing,  Ornithoptera alexandrae, first earned the title of the worlds largest butterfly in 1906, and in over a century, no larger butterfly has been discovered. This rare species, which lives only in a small area of Papua New Guinea, can measure over 25 cm from wing tip to wing tip. While thats impressive, a moth would hold the biggest living insect title if wing span was the sole criteria. The white witch moth,  Thysania agrippina, outstretches any other Lepidoptera with a wing span of up to 28 cm (or 11 inches). If youre looking for a bulky bug to anoint as the biggest living insect, look to the  Coleoptera. Among the  beetles, youll find several species with a body mass that is the stuff of science fiction movies. Giant  scarabs  are known for their impressive size, and among this group, four species remain deadlocked in the competition for biggest:  Goliathus goliatus,  Goliathus regius,  Megasoma actaeon, and  Megasoma elephas. A lone cerambycid, the aptly named  Titanus giganteus, is equally massive. According to the Book of Insect Records, researched and compiled by the University of Florida, there is no credible way to break the  tie between these five species  for the title of bulkiest bug. Finally, theres one last way to think of bigness when it comes to insects – weight. We could put insects on a scale, one by one, and determine which is biggest by grams alone. In that case, theres a clear winner. The giant weta,  Deinacrida heteracantha, hails from New Zealand. An individual of this species weighed in at 71 grams, though its important to note the female specimen was carrying a full load of eggs at the time she stepped on the scale. So which of these insects should be called the biggest living insect? It all depends on how you define big. Sources University of Bristol (2007, November 21). Giant Fossil Sea Scorpion Bigger Than Man. ScienceDaily. Retrieved March 22, 2011, from  ScienceDaily.Sues, Hans-Dieter (2011, January 15).  Largest Land-Dwelling Bug of All Time. National Geographic News Watch. Retrieved March 22, 2011.Evolution of the Insects, by David Grimaldi.Dudley, Robert. (1998). Atmospheric Oxygen, Giant Paleozoic Insects and the Evolution of Aerial Locomotor Performance. The Journal of Experimental Biology 201, 1043–1050.Dudley, Robert. (2000). The Evolutionary Physiology of Animal Flight: Paleobiological and Present Perspectives. Annual Review of Physiology, 62, 135–55.

The Rise of Christianity Essay Example | Topics and Well Written Essays - 1500 words

The Rise of Christianity - Essay Example Consequently, major rivalry occurred and still occurs due to division of various groups within the Christian religion. First century marked the beginning of Christianity mainly practiced by Jews. Christianity then spread to other areas of east and west. In Africa, Christianity spread due to missionary work and culminated to substitution of various African cultures and beliefs. During the transition age majority of Europe was under Christianity. Those who believe in Jesus are said to have internal peace and inheritor of another immortal life. Jesus performed various miracles before death and documentation exists in the bible. Additionally, following the commandments guarantees one access to eternal life (King James Bible Web). Consequently, reflection in the history of Christianity plays significant role in understanding development and growth of Christianity. This paper seeks to describe the rise of Christianity. Firstly, several stages and events characterize the rise of Christianit y. The most important thing that happened for the rise of Christianity to take place was the fall of Roman Empire (Caesars) that had established authoritarian regime in ancient period. Secondly, Jews played a central and important in the meaning of early Christianity. Thirdly, the coming of Christ for humankind was also significant followed by results of various teaching of the time. These teachings have the same effects to today’s society. Ancient Rome was characterized by authoritative rule of Caesar Augustus (Nardo 42-51). At the same time, transformations were taking place in Judea province. Additionally, Alexander the great was a great ruler who managed to overthrow Roman rule in Great Palestine and placed it under the watch of Ptolemy followed by Seleucids. Moreover, Jews returned from Babylon in 538 B.C with Moses rules and teaching as part of their belief systems. Torah was important in their religious practices based on the commands given to Moses by God. During this reign the Temple was a holy place that was accorded due respect. High priests were accorded maximum respect, as they had a special place in society assisted by Sanhedrin. Sanhedrin was important in implementation of Torah as laid down by Moses. Later, synagogue replaced the temple and was dominant as practiced by Judaism. However, temple was also a place of worship for Jews who were far away from Palestine. Moreover, Hebrews was translated into Greek to take care of Jews outside Palestine who practiced Greek as their language. Greek contributed to serious division in Judea but Greek prevailed due to support from pro-Greek Sadducees. King Seleucid declaration that temple be devoted to Zeus led to uprising by Jews who saw this as disrespect of temple. In 142 BC, Jews won this battle and were granted freedom (Nardo 45-59). The next rule after Judah was corrupt and this led to civil strife and war. However, Romans intervened and Palestine fell under stewardship of Roman. Herod was appo inted as Judea King and transformed the infrastructure. Pontius Pilate took over after Herod’s death. Most Jews hinged their hope on Jesus as a political messiah while others gave up and thought of Jesus as a spiritual leader. A section of Jews was impatient and advocated for revolution to get rid of foreigners and this resulted in a protracted battle with the Romans. Zealots killed large group of Romans in AD 66. At

Government Taxation Essay Example | Topics and Well Written Essays - 500 words

Government Taxation - Essay Example Property taxes are collected by home and business owners to pay city governments. Each one of these forms of collections plays a part in adequacy of revenue production, equity, economic effects, collectability and transparency. It is important to understand how these taxes are received and used through government spending. The government can predict the amount received based on the economy. Income tax is a large part of the receivable taxes that the government receives. Income taxes are collected from every individual who receives income. Even out of state residents are taxed. (Wildasin2010) All income made is reported to the IRS and taxed. Economic effects play a role in how much income tax is being received by the government. When individuals are not working and receiving income, the government is affected. The more income floating thorough the economy means more collectability for the government. The collectability is achieved when individuals and business file their tax returns. The filing of federal and state income tax returns allows for payment or the amount of income tax owed or is directly withdrawn from the payer’s income. The government has equity in the income that is made by individuals. The equity is in the form of taxes. This is true because individuals owe taxes. Owing the taxes is what allows the government equity.

International Marketing Environment Research Paper

International Marketing Environment - Research Paper Example Evidently, all these constraints affect the flexibility of doing international trade. A country while exporting its domestic products is benefited by the foreign exchange income as well as by the new employment opportunities. On the other hand, while importing goods from other countries, a ‘consumer surplus’ is being created when the consumers are benefited by the availability of better products at a lesser price. Utilizing the both benefits, government has the ethical responsibility to facilitate international trade to those who are willing to invest in the international markets. However, when considerations about the local market come to the surface, the introduction of the international trade becomes a job that is easier said than done. To illustrate, the victims of the international trade are the local businesses that are not able to compete with foreign products. In such situation, the role of the government becomes more critical on taking appropriate actions which will not badly affect both the groups. The foremost five levels of economic integration are Free trade area, Customs union, Common market, Economic union, and Political union. As the international trade is widening and more countries are ready and willing to invest in it, the level of economic integration has to be refurnished between various groups of nations. It is not practicable to think that all countries would follow the precise pattern of economic integration, but we can expect for the development of basic arrangements such as lowering and abolishing the hurdles to trade and creating an economical environment. New economic integration techniques must be brought up to cope up with the new international trade needs. As Holden (2003) points out, a most mentioned example for this is the European Union, which has evolved from a collection of autarkical nations to develop into a completely integrated economic unit. At the outbreak of globalization, economic integration had been one of the forces behind the international trade making. We can sort that fact out from the performance of the multinational organizations that have developed into the most profitable business concerns in the recent years. An organization must be aware of the culture and language of the country where it is going to make its huge investment. With the successful take off, international business will rely more towards the economic integration for its future achievements on the global scale. II. Economical and Cultural elements of International Marketing Environment Economic, cultural, political, technological, social, and legal elements are most important for the international marketing environment (The legal, political/ trade environment). Many write down the importance of economic element as, â€Å"With money all things are possible, without money many things are impossible†. The economic element plays a vital role in the international marketing environment. A technologically adv anced industrial product requires a technologically advanced buyer. In the same way, luxury products are not meant to be sold to low-income consumers. Therefore, international market for high-priced luxury items of food, furniture and durable products need large support of consumers who have the capacity to make large purchase from these hypermarkets. However, the global economic growth today has been at pace comparing to that of the previous year.

Vibrio Cholerae Cytolysin (VCC) Membrane Pore Formation

Vibrio Cholerae Cytolysin (VCC) Membrane Pore Formation Vibrio cholerae cytolysin (VCC) is a potent membrane pore forming protein toxin secreted by many pathogenic strain of the V.cholerae. In its membrane pore-formation mode of action, VCC belongs to the family of the ÃŽ ² barrel pore-forming toxin (ÃŽ ²-PFTs) proteins. VCC is secreted by the pathogenic bacteria V.cholerae in the form of water-soluble, monomeric, inactive precursor form of the protein, known as Pro-VCC. Proteolytic deletion of the N-terminal Pro-domain from this inactive precursor molecule generates the active, mature form of the VCC toxin. VCC induces colloid-osmotic lysis of the target eukaryotic by generating the transmembrane heptameric ÃŽ ² barrel channels/pores. The high-resolution molecular structural information is available for the water-soluble monomeric Pro-VCC form as well as for the transmembrane heptameric pore structure of the VCC. Structural analysis of the water-soluble monomeric form and the transmembrane structure suggest that the VCC follows the overa ll pattern of the archetypical ÃŽ ²-PFTs mechanism of pore-formation. However, the distinct intermediate steps leading the generation of the funcational membrane pore formation by VCC have only been characterized to a limited extent. Consistent with the generalized ÃŽ ²-PFTs mode of action, the membrane pore formation mechanism of the VCC is recommended to follow three different steps: interaction of the VCC monomeric unit towards the target cell membrane; formation of the metastable, transient prepore oligomeric intermediates on the cell membrane; and finally conversion of the prepore oligomeric assembly into the functional transmembrane oligomeric b barrel channels. Previous research work on the members of ÃŽ ²-PFTs including VCC suggest that the generation of the functional transmembrane oligomeric pore structure comprises the membrane insertion of the pore-forming stem region from each of the toxin protomer towards formation of the transmembrane ÃŽ ² barrel portions of the toxin. However, it has not been examine experimentally, in particular in the case of VCC toxin, whether the membrane insertion of the stem region could occur in the membrane-associate monomeric state of the toxin before the prepore oligomer generation or whether the prepore oligomer generation precedes the membrane insertion of the stem region of the VCC toxin. Even in the case of generalized ÃŽ ²-PFTs membrane pore-formation mechanism, such sequence of pore formation events has not been established precisely. Previous studies demonstrated that the engineered ÃŽ ²-PFTs (for example, VCC and staphylococcal LukF) not able to inserting their pore-forming stem region into the membrane lipid bilayer of the target cell membrane. Such protein variants, having their stem loop in a closed structure through the engineered disulfide linkage, are remaining trapped in their nonfunctional prepore oligomeric state. However form this observation it not clear whether the membrane oligomreization is absolutely necessary to trigger the membrane insertion or whether membrane insertion could be initiated before the prepore generation. Such perception can only be investigate by trapping the b-PFTs toxin molecule in its membrane-bound monom eric form without allowing the generation of the transmembrane oligomeric structures. In this order, a direct correlation between the membrane oligomerization and the membrane insertion has been demonstrated in Staphylococcal à ¯Ã‚ Ã‚ ¡ toxin, an archetypical member of the ÃŽ ²-PFTs family. Staphylococcal à ¯Ã‚ Ã‚ ¡ toxin containing a single point mutation has been shown to displayed defective membrane oligomerization of the membrane-bound protein and blocking the membrane insertion of the pore-forming stem loop of the toxin. This investigation suggests that, in case of Staphylococcal à ¯Ã‚ Ã‚ ¡ toxin, the membrane insertion event of the toxin depend critically on the prior membrane oligomrization step of the toxin. A similar pore-forming mechanism has been reported in the case of perfringolysin O, a prominent member of the subclass of the cholesterol-dependent cytolysin (CDC) under ÃŽ ²-PFTs family. Interestingly, streptolysin O, another prominent member in the cholesterol-de pendent cytolysin type ÃŽ ²-PFTs, follows a different mechanism of membrane pore formation that may have involve distinct sequence of events. In the membrane pore formation mechanism of streptolysin O, it has been proposed that the progressive assembly of the membrane-inserted monomeric unit of the toxin may act towards the formation of the transmembrane oligomeric pore structures of different pore sizes. A similar membrane oligomeric assembly has also been reported on another cholesterol-dependent cytolysin (CDC) class of ÃŽ ²-PFTs, pneumolysin. Thus, it emerge that the ÃŽ ²-PFTs member may not necessarily follow a common generalized procedure for the membrane pore formation mechanism of the toxin. It is, therefore, important to examine the sequence of the membrane oligomreization and insertion events for each particular member of the ÃŽ ²-PFTs family to elucidate the molecular mechanistic details of their membrane pore-formation action of the toxin. Many previous studies explored the molecular mechanism(s) of the membrane oligomerization process involved with the membrane pore formation action of the member of the ÃŽ ²-PFTs family including VCC. It is generally proposed that the association of the ÃŽ ²-PFTs protein monomer with the membrane component of the target host cells work as the triggering step to initiate the following events resulting towards membrane olgiomerization, membrane insertion, and functional transmembrane ÃŽ ² barrel pore formation. In particular, lipid components of the membrane like cholesterol have been extensively involved in the regulating of membrane pore formation process. In the mode of action of VCC, the presence of cholesterol in the target membrane lipid bilayer has been reported to be an imperative requirement for the efficient oligomerization and functional membrane pore formation by the protein. Cholesterol appears to regulate the membrane pore-formation of the toxin by physically binding with the protein molecule and not by modulating the physicochemical environment of the target host cell membrane. The molecular mechanism of the membrane oligomerization in VCC has been explored only to a limited extent. In particular, the membrane interaction mechanism of the monomeric units of the VCC toxin, which probably acting to regulate the membrane oligomerization process of the VCC toxin, has not been explored so far. Structure analysis of the VCC oligomeric highlights the major interprotomer interactions between the neighboring monomer units. The most significant interactions are observed between the amino acid residues within the membrane pore forming stem loop of the toxin. More importantly, blocking the stem loop in its prestem configuration has been to abrogate the functional transmembrane oligomeric pore formation (SDS-stable oligomeric assembly) without any effect on the generation of the prepore oligomeric species (SDS-labile oligomers). It has been reported that, even i n the physically absence of the stem loop, a truncated variant of VCC can generate prepore oligomeric assembly on the membrane. These observations precisely suggest that the interprotomer interactions involved in formation of the functional transmembrane oligomeric pore assembly without playing any critical role in initiating the membrane oligomerization event of the membrane-bound protein molecules. Therefore, it appears that the additional molecular interaction between the monomer of the toxin might be playing the significant role in inducing the functional membrane oligomerization of the VCC toxin. In this part of study, to explore the details of the molecular mechanism of the membrane oligomerization process of the VCC toxin, we have mapped the key amino acid residue in the VCC molecular structure that are crucial to trigger the membrane oligomerization of the membrane-associate monomeric toxin molecules. Mutation of such key amino acid residues abrogates the membrane oligomerization step, trap the toxin in its membrane-bound monomeric state, and does not allow membrane insertion of the pore-forming stem loop form the VCC monomers. Our study, dissect the membrane interaction step from the following membrane oligomerization and insertion steps of VCC as a prototype in the b-PFTs family, This study also conclusively established that the membrane insertion critically required the functional oligomerization of the membrane-associate VCC toxin monomers on the target cell membrane.

Leading at a Higher Level

IntroductionThe book under consideration is named â€Å"Leading at a Higher Level† and this extraordinary book was written by Ken Blanchard. The author has previously written numerous books namely The One Minute Manager, Raving Fans and now this book. The books written by the aforementioned author have turned out to be helpful for a number of people in perfecting their own leadership skills and expand the prospective of those around them.Now, in Leading at a Higher Level, Ken Blanchard discloses the answers to superlative leadership. Anyone and everyone can profit from the recommendations in this book that have previously helped thousands of leaders and business’ become more oriented around its people, centered on the satisfaction of its customers and performance-driven. The author introduces the readers to innumerable concepts such as the â€Å"triple bottom line† and how to use it to generate effectual objectives and visions.The book provides the readers with t he ways to determine ways to turn customers into what the author calls â€Å"raving fans† and build up a proper â€Å"customer mania.† Any of the higher authorities of an organization can use the techniques presented by the author in his book their own guidance, for leading teams as well as complete organizations. It can also help one in finding their own individual â€Å"leadership point of view†, which is a skill that all really great leaders have power over and it is also helpful in finding out how to relate it all the way through your entire life. By the use of this book, regardless of who or what place you are at, one can produce high-performing business; that can ease out life for everyone. Hoist your game, improve your presentation and make sure that you are foremost at a higher level.ReviewAs said, â€Å"Leaders in any realm of life can become self-serving when the driving reason for being in business is based solely on profit. While profit is a legitim ate goal, neglecting to see leadership as part of a higher calling diminishes the capacity to influence others and impact the greater good† (William, p.1). Leading at a Higher Level scrutinizes the notion of leading with a higher rationale, which necessitates a persuasive visualization and a way of life that the expansion of people is in the same way important to that of presentation. Author Ken Blanchard dares readers to show the way by asking themselves about their own realities, what they position for, and how they can take the inventiveness even if they do not have authoritative power.In the aforementioned book, the author along with a number of his colleagues has made the efforts to put forward their own understanding of top-notch leadership. By reading the book one can learn just how to create aims and objectives for the organization and the ways by which you can make your existence known as well as where your company is moving.Blanchard expands his step forward work on conveying well-known customer service and creating what he calls â€Å"raving fans.† In the book one will find the state-of-the-art dialogue of the well-known Situational Leadership II techniques for leading yourself, persons, teams, and complete businesses. Most significantly, Leading at a Higher Level the book is a big help if one wishes to take a good look at himself, determine the private â€Å"leadership point of view† and then use it for the rest of his or her life.  In the words of the author, â€Å"those who want to lead at a higher level need to understand what a high performing organization looks like and what is necessary to create one. They need to aim for the right target. Profit is the applause you get for taking care of your customers and creating a motivating environment for your people† (Blanchard, p.4).The author believes that anyone who wishes to become a better leader in any company, any organization, and any area of life needs to have a fi xed aim, follow the right idea, focus on the â€Å"bottom lines† that really matter at the same time as providing the customers with good support and deliver your ideal customer experience, and create â€Å"raving fans†. But most of all what he wants to deliver is that leaders should, â€Å"Listen, praise, support, guide, and help your people win† (Blanchard, p.5).The book is extremely informative when it comes to learning how to lead your people to enormity as you create elevated performing organizations that make life better for everyone. This book will direct you, motivate you, incite you, and be your criterion. Ken Blanchard along with a vast number of his colleagues are people that have spent a number of years in serving good leaders and organizations become grand, and as well as stay that way. In this book, they have made an effort to bring together everything they have learnt in the years gone by. By this book one can discover how to, â€Å"Go beyond the short term and zero in on the right target and vision, deliver legendary, maniacal customer service, and earn raving fans, truly empower your people and unleash their incredible potential, ground your leadership in humility and focus on the greater good† (Blanchard, p.10). Since a very long time, a vast number of people have benefited from the insight, understanding, and convenient procedures.From my personal point of view, the book is excellently written providing examples from the lives of real leaders. The book has been written in a very exciting manner and one can not get bored while reading it. Speaking for myself, I have not found anything negative about the book.ConclusionIn the light of the above discussion we can hereby culminate that the book that has been mentioned above namely Leading at a Higher Level was written by Ken Blanchard and the book is related to the ways in which leaders can understand themselves and then lead themselves, their teams and the entire org anizations on the way to success.Works CitedBlanchard, Ken. Leading at a Higher Level: Blanchard on Leadership and Creating High Performing Organizations.   United States of America. FT Press. 2006 Pp. 4,5,10.Williams, Susan. Leading at a Higher. Financial Times. 2007. Pp.1.